DNA pairing is an important step in the process of targeted nucleotide exchange
نویسندگان
چکیده
منابع مشابه
DNA pairing is an important step in the process of targeted nucleotide exchange.
Modified single-stranded DNA oligonucleotides can direct the repair of genetic mutations in yeast, plant and mammalian cells. The mechanism by which these molecules exert their effect is being elucidated, but the first phase is likely to involve the homologous alignment of the single strand with its complementary sequence in the target gene. In this study, we establish the importance of such DN...
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M eiosis takes the genetic variation from the parents and scrambles it before passing it on to the progeny. This partitioning is accomplished by two phenomena. First, because the genome is fractionated into chromosomes, the random segregation of nonhomologues transmits different parental contributions to the meiotic end products. Second, crossing over between homologous pairs of chromosomes cre...
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PRINCIPLES OF HOMOLOGOUS PAIRING AND DNA STRAND EXCHANGE . Homologous Pairing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . DNA Strand Exchange . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Energetic Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Experimental Assays . . . . . . . . . . . . . . . . . ...
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چکیده ندارد.
15 صفحه اولThe guanine-nucleotide-exchange factor Cdc24p is targeted to the nucleus and polarized growth sites
Generation of cellular asymmetry or cell polarity plays a critical role in cell-cycle-regulated morphogenetic processes involving the actin cytoskeleton. The GTPase Cdc42 regulates actin rearrangements and signal transduction pathways in all eukaryotic cells [1], and the temporal and spatial regulation of Cdc42p depends on the activity and targeting of its guanine-nucleotide exchange factor (GE...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg171